I'm really liking this setup (just put it together after a week of testing on VMs).
I put Comodo in "Internet" setup and changed all the settings from there (I like the zone checking; I don't want to be nagged about files I already have.), have HIPS in training mode for a few days (otherwise I imagine I'd uninstall it after the 42nd prompt and hour later), auto-sandbox and viruscope on everything. It's been as quiet as Windows Firewall (one unsigned app that talks on the network needed approval and a Win10 process).
I really like Qihoo 360 and, TBH, I didn't expect much from it but I had to explore all options (especially since they are limited on Win10--Avira and may others don't run on it). It has Avira & BD engines and two of it's own, so it really is hard to go wrong with that and it's performance is better than Windows Defender, so it's an upgrade all around. Funny thing is, the QVM engine was a bit more sensitive on my full scan than Avira/BD: it heuristically flagged several fritz chess engine packs (self-extracting executables) I have from ~13 years ago.
It also has a behaviour blocker/logger that is really cool: it will prompt you for serious actions (like an unsigned program modifying a startup item) but only notify you with probably-normal-but-just-in-case-it-isn't behaviours (signed, known program modifying startup).
The only have the "Total Security" version for Win10 at the moment (I prefer the "Essentials" version) that has system cleaner extras (like all the suites are doing and I hate that--you'll never beat CCleaner!) but they aren't bloated or obtrusive or anything like that. They can be completely ignored. Disable the sandbox feature though; I believe I've seen it interfere with detection with Comodo installed (with it's sandbox); it's redundant anyway.
I don't use Qihoo's web filtering and I haven't tried it. I'd have to research it more and I'm happy with Chrome/Google DNS, uBlock Origin (I just switched from AdBlock), and Avast's Chrome plug-in (though I'm looking for an actual performance test of online security plugins since they are independent of the security product, so I may change that). I did add Winhelp's hosts to Comodo firewall to keep Project Spartan (Microsoft Edge) from being ridiculously stupid with ads. My wife saw that today and remarked, "The Internet is crazy with all those ads!" Indeed. Reminded me of the movie, Idiocracy.
Anyway...to the OP: Both! Qihoo 360. heh