If a security soft ranks amongst the top performing AVs, it won't matter much if it does function correctly or causes problems on your specific system.
From lab test results F-Secure has an edge over Panda during testing the past few years in terms of detection (although higher false positives).
From users, it seems more prefer Panda - which is one of Neil Rubenking's (PCMag) favs (that don't mean much - but that is just my opinion).
I'd say, in terms of overall protection, Panda has a slight edge; it might protect your system in a few instances that F-Secure will not.