If you could rightly configure them, yes they could run side-on-side. One will provide realtime on-access protection (creation and modification of files) while the other only on execution. Check out Umbra's Guide on how to run two Antivirus products. But again, the additional protection would be so minimal, if not, nothing at all.
If you want two AVs to run, then choose MBAM Pro or WebRoot as they are designed to be complementary AVs.