I haven't used Panda Antivirus Pro to make a fair comparison, but out of the box experience with Norton is almost flawless. Norton Security is a full suite with Antivirus, Antispyware, Behaviour Blocker and Firewall, with Cloud + Reputation scans.
From Panda, I have only used their Free Antivirus, but it would be unfair to make a comparison when it comes to features and levels of protection, however, Norton felt a lot less sluggish on the system (old system: Intel C2D 2.2GHz, 3GB DDR2 RAM).
@King Cobra In the future, I would not check "Allow multiple votes", for these types of Polls.