Adguard gets my vote, you can replace Ublock Origin with it by adding the much of the same filtration and eliminating overlap between the two plus you get Adguard stealth mode and all its features and there is the advantage of having one less extension thus a little bit better fingerprint non-uniqueness.
As others have said - Adguard is great for system wide blocking and uBlock origin is great for browser, personally i like uBlock origin cause I don't need system wide blocking and uBlock origin has other useful features like webrtc blocker etc.. Personally when I tried AdFender it was rubbish, let adds through and crashed etc but that was a little while ago.
I used to use Addblock Plus, but people on this forum put me onto uBlock origin and I have to say it's the best for browsers.
I used to have Admuncher for many years and found it pretty good for getting rid of system-wide adverts, and now its free, but I dont have it on my current system, as apps these days dont seem to suffer from ads as much (well apart from TuneIn radio & AVG products), and those that do I tend to fix by disabling the ad source in my hosts file.
I still have Peerblock, which isn't really an ad blocker, but prevents a lot of nasty intrusive pop-ups etc. Although its lists are fairly old and its not really being supported anymore it does stop a surprising amount of 'bad' stuff. I haven't tried Adguard, but it does sound useful.
This is a tough question as both are good products.
Without the licence, I use uBlock Origin for the reasons already stated in post #5. The speed and the manual blocking capability is unmatched. I use it for Chrome (my default browser) and Firefox. I use AdblockPlus for Edge and IE due to lack of free alternatives.
With the license, I'd keep AdGuard for 6 weeks, then switch for 6 weeks (or until I missed what AdGuard brings).
I'd have to go with Adguard. Doesn't slow down browsing where ADP does with Internet Explorer. Isn't the whole point of an adblocker to speed things up. Not to mention ADP has had some shady practices in the past.
I use Adblocker Ultimate firefox extension i would think it does the same thing as adblock plus but adblocker Ultimate allows you to clean up those annoying flash ads that adblock plus may miss by few clicks here and there you can make any object on the web page you find undesirable vanish
I switched from adblock to Ublock and never looked back. Ublock coupled with the Palo Alto firewall blocking ads, google-analytics, crashalytics, anything in the web-advertisements category I haven't seen any ads in a long time. I forget they exist then I use another computer and I am shocked at the amount of ads all over the internet.
I have not tried adguard but I don't see a need for it, maybe I will try it out just for fun