Several experts, companies, and national entities have voiced very convincing concerns about DoH and its features.
www.zdnet.com
It is up to you really, I myself would prefer DoT or dnscrypt over DoH, but given the lack of a choice, DoH is somewhat better than the default DNS, at least in preventing some MITM.
As to the question itself, I am intrigued, since I have installed Windows Dev just to get Windows DoH support and I wonder: Is it better to let Windows handle DoH or Chrome?
P.S.: DoQ would be probably the best choice, but given how "fast" is MS in introducing new features, that will not be a question for another decade.