Hi advanced_skill,
One glaring weakness of CIS is that it has poor malicious URL blocking. That's OK because you can correct it by importing a URL blacklist on a regular basis.
To find out how go to the Comodo sub-forum here at MT. Search for Umbra Polaris' guide.
Check out the other excellent tutorials.
Back-up: Macrium Reflect free, AX 64 or Comodo Backup. With backup apps there are a lot of quirks so I would research thoroughly.