I have Comodo Firewall at CS settings. I also have enabled HIPS ( it took me 15 minutes in learning mode to click on my main apps) No issues on Windows 10 and Comodo is very quiet. In the last 2 years, I had one problem: Comodo opened a window whenever I ran Chrome. It took Comodo a few weeks to find a fix. I disabled the web filter: I use Emsisoft Browser Security.
I have a backup of my settings so the installation of a new version of Comodo is super fast.
Windows Defender is my antivirus.