HI Thanks but have to disagree with your comments based on personal experience
(1) Avast, Avg, MBam and Msie do not detect low level nasties and spyware pests which I find and remove regularly from my two sons computers which are detected only by Spybot which I use to remove together with ADW cleaner .Very recent examples Ilivid, Babylon, Delta toolbars , MyWebsearch and Searchnu . I have read Spybot also vgood for stopping keylogging. (but I use virtual keyboard )
(2) Mbam Pro often flags up types of malware missed by Avast on mine and sons pc's , yesterday in fact.
(3) Win Patrol is very light on resources and unintrusive , it proactively monitors my pc and gives alerts of every programme or file trying to instal itself or any trying to change my internet homepage. Twice ive had nasties in past repeatedy reinstalling themselves despite file and registry deletion ,rebooting etc with a complete failure by AVG ,Mbam and Spybot to detect/ remove.One of these was malware opened from a notorious "Hallmark Cards" email.
Only way I could finally remove them was by using Win Patrols excellent "delete at boot up" facility.
As a heavy PC & internet user I find that employing several different types of specialist malware/spyware/monitoring programmes together with Sandboxie gives me and my family the best possible defence against the current great variety of pc infections.