of the 4 you've been using, do you favor one over the others...
Harmony great detection; more FP and heavier on resources, standalone. Heaviest and very noticable resource impact when opening new files or loading webpages that are rich in input fields (like forms etc). Heavier than DI + Windows defender and Cylance+ESET Home.
Deep instinct good detection, some FP, resource impact not noticable but I am running it along with Windows defender
Bitdefender detection between DI and Harmony and the space is very tight so not much room and difference between them. False positive rate I would say equal to DI or a tad more, but nothing to write home about if you know what subsequent steps to take in order to verify validity of the file. Stand alone
Cylance worst of them all in terms of detection, running along side of ESET home just for memes. Some pact on resources but it doesn't find anything that ESET doesn't and it misses what ESET finds. Not recommended.
But I am not really malware hunting. The width and breath of my malware hunting playground is cracks, not because I use pirated software but because it's rich with malware aimed towards the "PcMasterRace"/geeks. So none of it is aimed at corporate espionage.