Antivirus:Sentry: All Files or Specific Extensions(VBS,HTA & many more)
Add-Ons: Check

Office Plugin.
System Monitor: High level of Protection
Unchecked Automatically allow all files that are Digitally signed/recognized by system Monitor.
Checked Always prompt if new software is installed when changes are found.
SCANNER: What to Scan: All Files
System Areas to Scan: Checked All blank space.
Data Locker: Add anything that you need to protect.like C:\User\captain\Desktop
Untick Use Smart Analysis to discover trusted Applications.
Firewall: Applications: You can manually add safe applications.
For Extreme caution: Select Deny Access(I prefer this all the time)
Normal cases: Prompt for action
Checked the Show alert when denied box.
Intrusions: Checked all boxes.
General: Tick the Display Critical Alerts.