It's all good until CCA auto-sandboxes an "Unknown" critical, safe\legitimate system file or driver and boinks your system.
Easy enough fix you say - just change file rating from Unknown to Trusted ? It doesn't always work... at least that has been my experience, especially with Unknown drivers - for example AMD system drivers.
From what I understand, CIS and CCA are using the same, identical Safe List database.
However, Comodo's file rating system (Safe List) is still a major problem since many core Windows OS files have yet to be added and rated as Safe. Some are absent because they never get submitted. Others are digitally unsigned (contrary to popular belief, Microsoft does not digitally sign all of its files).
With every Windows update, many - many files are auto-trusted by CIS because msiexec.exe is a Trusted Installer. Therefore, none of those files every get submitted to Comodo; only Unrecognized (= Untrusted\Unknown) files are submitted upon execution . Furthermore, it is suspected that Comodo does not have any agreements with Microsoft or other OEM vendors to gain access to files, drivers, updates, etc - and have them white-listed so as to not block them on user systems.
This is a long-standing, ongoing issue with the way Comodo's Safe List database operates.