Please note that I feel that running hundreds of malware (not knowing what they are or how old) at once is also not optimal.
But consider:
1). Just say you were working for a company like Endgame and wanted to discover a Windows Exploit in order to sell it to MSFT for a substantial payday. The most efficient way to accomplish this would be to know Windows inside and out, find a weak point and then code an Exploit that you happen to "discover".
2). Or, you can also not really know how Windows works, find as many different pre-existing exploits as you can on the darkWeb, and then run them. Find one and you will accomplish the same thing as in the previous example, but just in a much more inelegant way.
So it is with malware testing- some just will install a product, click on various options and run a whole lot of (hopefully) malware against it. Others will actually Know the product, know (or code the appropriate malware, and select these to demonstrate a point.
But in both of these cases a bypass is a bypass (Christ, I'm sticking up for Leo. Please KMN).