Sandboxie + Windows Defender = a good combo!

[JM Safe]

Yes it is why i usually select solutions with the less impact on the OS stability/performance and compatible with my other apps.

The best security software are the software well balanced for impact, compatibilities and security.

 

[Wraith]

Obviously remember also on-demand scanners (I didn't mention that in the thread but it's important).

Yes indeed. My personal favourites are HitmanPro and ESET Online Scanner.

 

[JM Safe]

Yes indeed. My personal favourites are HitmanPro and ESET Online Scanner.

Yes, Hitman Pro and ESET are very popular and reliable ondemand scanners.