First off, sorry for the rant. I like making my post through. May be littered with spelling mistakes and all that.
Well I haven't been infected in a very long time but I've been infected with ransomware, rogue AV, etc but most of all adware. The truth of the matter is, malware is supposed to operate without you knowing that it's there for the most part - unless it's a rogue AV or ransomware which needs you to know that it's there. Infections can go years without detection and therefore I can't in my right mind believe anyone who says they've never been infected (no offense, that's just my point of view - everyone starts somewhere, you aren't born with the ability to know what files do when you run them or what happens exactly when that file is malicious and you run it). If you learn IT before you actually used a computer (which is highly unlikely) then I might believe you. I expressed this on MT many times before so I'm not trying to target anyone by saying this here.
I used to just reinstall the whole system but with Paragon I just restore it (I mostly do this to simply refresh the system if I keep uninstalling after I set the backup). In my opinion, it's better to reinstall then backup (if your truly infected - ESPECIALLY with ransomware if you are running your backup program within the infected OS). Never know if that malware is going to intervene on the restore process. Just reinstall your backup software and immediately restore after you install your backup solution of choice to use those backup files. Done. Now unfortunately, my back up is on a secondary HDD that's internal and always connected (because my media files are there - music, etc) but the backup is on another partition. Chances that my backup could be ruined or infected is pretty high. I have to work with what I got at this point.
I also dismount the partition to protect it against such things while allowing my media partition to stay mounted. Everything in there is backed up with OneDrive and it's never on unless I need it to sync so even if ransomware hit, I just delete the partition, format, redownload data. The ransomware wouldn't be able to overwrite or upload to my OneDrive when it's not syncing at all times. If any of you DO leave your sync on at all times, I would highly recommend not doing so.
Nowadays I never run a file without running some kind of sandbox with it to see what it does. That includes using VirusTotal and malwr, Valkyrie, etc. Of course I don't do that with trusted files. And some are just to big to run that way unless you have Sandboxie or something which I don't. I'll probably buy it this year however. I download files all the time so having a sandbox that only cost $20.95 USD a year isn't bad at all.