RE: Config
Real Time Protection:
What security product did you use last time? I strongly recommended giving CIS 5.8 a try ...it's free and a very solid layer of protection.
As for Windows Defender it can be disabled as it's almost worthless..
Comodo Internet Security (Free) -
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Comodo Internet Security is the free, multi-layered security application that keeps hackers out and personal information in.
Built from the ground upwards with your security in mind, Internet Security offers 360° protection by combining powerful Antivirus protection, an enterprise class packet filtering firewall, advanced host intrusion prevention and automatic sandboxing of unknown files.
Additional browser plugins
You can create and secure your passwords with this great addon :
LastPass (Free) -
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LastPass is an online password manager and form filler that makes web browsing easier and more secure.
A site advisor is a must-have when browsing the internet ...
WOT (Free) -
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To help you avoid malicious sites you can use Web of Trust (WOT) a website rating browser plugin. After you add it to your browser make sure you only visit websites rated "Green" by WOT
Additional on-demand scanner:
Hitman Pro (Trial) -
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An on-demand scanner using multiple anti-malware engines and cloud technology. It offers unlimited free scanning but once you use it to remove detected malware it switches to a 30-day trial version. I recommend using it after you've scanned your hard-drive with the other products you have installed.
Malwarebytes Anti-Malware Free (Free) -
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Malwarebytes Anti-Malware Free utilizes Malwarebytes powerful technology to detect and remove all traces of malware including worms, trojans, rootkits, rogues, dialers, spyware and more.
You should use a virtual environment when browsing or opening unknown or suspicions sites or apps.
Virtualization:
Sandboxie (Free/Paid) -
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Sandboxie runs your programs in an isolated space which prevents them from making permanent changes to other programs and data in your computer.
Extra protection:
EMET 2 (Enhanced Mitigation Experience Toolkit) (Free) -
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EMET provides users with the ability to deploy security features built into Windows to arbitrary applications. This helps prevent vulnerabilities in those applications from successfully being exploited. DEP, SEHOP and ASLR are such security features, if you want to learn more about what they do, you can watch this
video from Microsoft TechCenter. To configure EMET you should follow this
guide by rationallyPARANOID.