Most AVs use heuristics... one notable exception is Emsisoft.
All the AVs that use heuristics allow the user to set the heuristics algorithm: Low - Medium - High.
High is aggressive - it might detect legitimate files - especially some WIndows system files, like Microsoft Malicious Removal Tool or something similar.
High is a huge system resource hog that will very likely double, if not triple or quadruple, the time required for a full-system scan and place high load on CPU.
For example, Comodo using Low heuristics will complete full system scan in about 40 minutes on my specific system. Using High heuristics it takes 2.5 hours. CPU load remains consistently in 75 to 100 % range during entire scan - and causes other apps to misbehave or not work at all (this is expected behavior under such high CPU load for all AV - not just Comodo). (On your system results will very likely be different - but follow the same trend).
You will find the same trend with all other AVs that use heuristics.
Who has "best" heuristics?: Avira, BitDefender, and Kaspersky.