Simple. Offer the target an installation file. Then, attack!It is enough for untargeted typical home user to protect physical system, but for targeted systems it can do little except perhaps delay the inevitable.
Targeted systems - like most government agencies - are doomed to be hacked sooner or later - no matter what security softs are being used.
If home user system is targeted, same result = smashed.
The question is whether AppGuard would delay the inevitable by a few hours up to months or longer. That all depends upon the hackers - their determination, resources, skill, what they are attempting to do, use social engineering, etc.
No security soft can guarantee protection against targeted attacks -- despite what claims are made by the vendors, fanboys, etc.