At any time in the free version you can not, but you can open it with the right button and will be in the sandbox any application, with Sandboxie.
And also with Comodo as you know.
Windows Sandbox is a new lightweight desktop environment tailored for safely running applications in isolation. How many times have you downloaded an executable file, but were afraid to run it? Have you ever been in a situation which required a clean installation of Windows, but didn’t want to...
I've used Sandboxie for a long time, but 2 years ago I replaced it for Comodo Firewall.
I disabled Windows Defender, I only use CF and I isolate everything I want, but mainly Chrome.
It's a simple setup, safe (for me), and with great performance.