Thanks everyone for taking their time to review my config. Since I posted it, I've been experimenting with two minor tweaks.
I'm using DuckDuckGo instead of Google as my search engine, for starters. I understand that the results may not be as comprehensive, but whichever engine I'm using is really a compliment to Opera's Speed Dial more than anything else. If I'm not satisfied, I can always just bring Google up with the shortcut key.
The other tweak is disabling Windows Defender in favor of Crystal Security. This is on a trial basis more so than DuckDuckGo. I'm basically trying to go as minimalist as possible without compromising security. I feel like Webroot would be an ideal companion piece, but I'm not willing to splurge on an anti-malware solution. I haven't noticed any issues so far, with the exception of a popup chain when Opera tried to update itself.
If you guys have any thoughts to share, they're more than welcomed.