In response to the topic title Best Security Combinations?. It's better to use an updated Operating System, Antivirus or Anti-Malware, or Virtualisation, Modern Firewall with Hardware Firewall on your Router, Knowledge of common Internet threats and risks. If you have young users, maybe use a DNS by Norton or another vendor to filter out content you don't want them to get involved with, or for yourself.
As for the Best AV Combo?, I wouldn't really recommend anything. One, because there isn't any good combinations that will provide the best security and Two, 2 Antivirus software cannot stop human error - by yourself or another. So a better security config would really on a layered approach, as already mentioned.