Honestly, As much as I like Comodo and that its free but in terms of Protection I think Bitdefender wins.
Comodo is dependent mostly on Defense+ and when I test Comodo without D+ its detection is average and it gets a good amount of FP's. Many people do disable D+ because of the nag and I noticed it in personal experiences on working with computers with comodo.
Bitdefender has amazing detections with little FP and doesn't depend on a HIPS if you have it disabled.
and I'm really tired of people choosing a product because its "Free" in the war room. Yes its free but what about protection, user friendly, memory usage, etc.