Its a known combo, but ensure to exclude COMODO firewall from ESET.
Also, ensure you either use COMODO's Defense + or ESET HIPS.
To exclude COMODO CFP.EXE and CMDAGENT.EXE (Umbra, correct me if I am missing something), please open ESET, go to advanced settings, and under Real Time protection, select exclusions and add the EXE's.