It was meant to be more tongue in cheek than anything. Although Comodo has had more than it's fair share of FP's from the amount of time I've been using it.
As far as I know CCE detects all RunOnce registry entries as malware.
If you just recently installed a new program or updated a program that requires a system reboot, then RunOnce registry entries will be created.
If you delete these RunOnce registry entries it will corrupt the program.
Also applies to Windows Updates and driver updates.
CCE also detected WinPatrol and Sandboxie after I updated them because of the RunOnce registry entries.
CCE has far too many false positives even though all security scanners have the occasional false positive.
I have seen the false positives too, on a few products as well as this one, and was under the impression we were here to share that facts, doing so with a little tact.