If you disable the setting "Predict network actions to improve page load performance" to speed up Chrome/Dragon/Iron, and clean with the default "history" option checked in CCleaner, then it will re-enable the setting. It has done this now since version 3.23.1823 and Piriform has been notified, but the don't seem to care. CCleaner is the only drive cleaner that does this. Wise, SlimCleaner, System Ninja, ect... all don't do this.
If you haven't tried disabling that setting, give it a go, I think you will be impressed how much quicker Chrome loads, especially on a page with 100's of links on it.
EDIT: BTW, with "history" checked, I analyzed with CCleaner, then I added everything it found in the history section to the exclude list. Then I re-analyzed again, and it found nothing at all in history, however, if I then hit clean with history checked (even though there is nothing to clean) it will still re-enable the setting. So it isn't as simple as "just exclude the folder/file that causes the issue".