+1 on javascript blocking.
I use the "Quick Javascript Switcher" extension to augment Chrome's scripting rules so I can easily toggle scripting on/off. I find it is very handy for sites with anti-adblocker scripts that load a semi-opaque mask that Adblock struggles to defeat.
Re: Chrome's Privacy checkboxes... all are unchecked, except "Protect you and your device from dangerous sites", because none of those features seem pro-privacy to me.