To my view, Comodo and Emsisoft are the best protection possible if the user knows some things about the computer and knows how to handle some situations (especially with Comodo).
I 've recently completed tests in virtual machine with most well known AV's and noone could touch Comodo or Emsisoft. I 've tested them with various sets of samples uploaded here and ran all undetected samples every AV left. All the rest left viruses running on the system while those two left none running (Comodo autosandbox setting was on untrusted) as MBAM quick scan and hitman pro indicated. Not sure about Emsisoft as the specific test with it was a bit rushy, the rest not. The system was Windows 7 with all updates installed.
Sorry for not publishing a video, meybe I 'll do it sometime. xD