A few tips:
Enable UAC (at least for default, even if you bother)
Could Add: Malwarebytes, EEK or even HitmanPro for weekly scanning
Add CCleaner for a general cleaning
Unchecky against Pup's
Add any Backup or storage in cloud
Could maybe use a Google Chrome (Having a larger library security extensions, like adblock, Ghostery, WOT) or even take a look at some for Internet Explorer
With ESET and advanced level of knowledge, you're safe
Good Config + Others tips