Haven't tried it but the first thing that comes to my mind is that the traditional DNS could be seen as a privacy issue. So when it comes to protecting your privacy from someone listening to your connection DNSCrypt is a small step forward. As we all know DNS is used to retrieve the IP address of the server we are connecting to. Someone listening to our connection could for example determine that we are connecting to certain sites even if we are connecting using SSL because traditional DNS is not encrypted.
I don't think it solves many other security issues besides privacy though and you have to trust OpenDNS to use it and run yet another application on your system (give up on some resources). Also it is only useful if you connect to a certain website using SSL, otherwise the rest of the traffic is not encrypted. Plus this is not a new standard (as opposed to DNSSEC) it is just a feature of one of the DNS providers that offers point-to-point encryption of your DNS queries.