Email Clients and Two Factor Authentication ?

[Aleeyen]

If I enable Two-factor authentication in my email service, will I be able to open my emails in email clients, like Thunderbird?

 

[Razor555]

If I enable Two-factor authentication in my email service, will I be able to open my emails in email clients, like Thunderbird?

The only thing i know is to keep away from Microsoft email accounts.
If you have any issue they will not help.