I have not tried Win 10 until now, so I cannot vote here. But I hope to compare them in terms of behavior blocker.
Some double-click tests (real-time scanning disabled) conducted by the users show that, the behavior blocker of F-Secure, which is called
DeepGuard, has a good prevention rate against malwares. This module uses not only the cloud-based reputation, but also local-based behavior analysis. Therefore, it can work well even in the offline status. It is also confirmed by the Behavior Blocker test of AV-Comparative, which is conducted in the offline scenario. In 2015, F-Secure won the second place in this test:
http://www.av-comparatives.org/wp-content/uploads/2015/07/avc_beh_201503_en.pdf.
By contrast, I have seen many people complaining the poor prevention rate of the behavior blocker of avast, which is called
DeepScreen. What was worse, I heard that DeepScreen nearly could not work in the offline scenario, though I have not tested this by myself.
As mentioned in the above posts, a good thing of avast is its aggressive hardened mode, which can be viewed as an application whitelist. But it seems that this function highly depends on the cloud. Furthermore, if my memory serves me right, it can only block EXE files, but cannot block scripts & dlls.
Since you are using the
Enterprise version of Windows, you can construct your own local application-black/whitelist with SRP and AppLocker.