I used Forticlient on my old XP pc for some years now, and I have to say that it is very decent and light. It is actually one of the very few antivirus solutions that does not slow down this old pc. Also the firewall was very good and you were able to configure it for every app you have on your pc, but they removed it since version 5 I think. It is now only available if you buy the product.
Although it lacks a good zero-day module (apart from the heuristics) it is still very good. It did some test with it a while ago and it always stopped lots of treaths, even if they were quite new it did well if you know that it only relies on signatures. As somebody mentioned above, it indeed stops adware, but I think that you have to enable it in the settings. You can also upload samples and they are added to the database really quick. The only bad thing is that the database is quite large, so the first update can be very slow.
Probably the best feature in the product is the web protection which definitely deserves more popularity, since it blocks malware and phishing pages very well. I've tested it with lots of new links, and it almost stopped every bad url. The web protection can also be used as a kind of a parent control, because it is as already mentioned above, highly configurable and has lots of site categories to block.
Although it is a very simple product, and it lacks some zero day component, it can be indeed very effective in combination with comodo firewall or something similar.
If you search something else than the popular free av's or need something that is light on resources, it is definitely worth trying, but in combination with something else.