Scientists at Linköping, Lund and Gothenburg universities in Sweden have forged electrodes in living tissue using the body’s molecules to trigger them. The researchers are the first to successfully do this without the need for external signals or by modifying genes.
In experiments conducted at Lund University, a gel containing enzymes as “assembly molecules” was injected into zebrafish and medicinal leeches. From this, the scientists observed that electrodes formed in the brain, heart and tail fins of zebrafish and around the nervous tissue of the leeches. The animals were neither harmed by the gel nor adversely affected by the electrodes. “By making smart changes to the chemistry, we were able to develop electrodes that were accepted by the brain tissue and immune system. The zebrafish is an excellent model for the study of organic electrodes in brains,” explained Roger Olsson, professor at the Medical Faculty, Lund University.
Generally, implanted objects are required to kickstart electrical circuits in the body. Not surprisingly, it took the team several years to develop the gel, which required the right structure and components to be successful in animal cells. "Contact with the body’s substances changes the structure of the gel and makes it electrically conductive, which it isn’t before injection. Depending on the tissue, we can also adjust the composition of the gel to get the electrical process going," said Xenofon Strakosas, PhD researcher at the Laboratory for Organic Electronics (LOE), Linköping University.
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