my own admittedly unprofessional approach is to see if I can find someone writing about the file on the web. If it already has a write-up, it can't be too new, and VT should know whether it is clean or not.
edit: but you still have to check whether the file is in the right location, or it might be malware named after a legitimate file.
For instance, if Adobe released a new patch that has file X, and this file turns up in your Adobe folder, it is probably legit.