I was using CIS on Windows 10. I had issues where it was blocking non Microsoft metro apps like Twitter and Candy Crush with it's sandbox and I couldn't figure out how to whitelist them but other than that I got it working. You can't use the installer cause it says not compatible. You must open the installer with 7-zip and navigate yourself to the msi file and installer it through the Windows installer.
Comodo has announced that they are indeed working on updating CIS with Windows 10 compatibility. But if you are unable to wait then it is possible for you to install it onto your system right now.