How's that? If you mean Intel® Virtualization Technology for Directed I/O (VT-d) that is disabled I don't think it will make any difference, explicitly if VirtualBox or VMWare are giving you errors of unsupported model.
I wouldn't see why you couldn't use it for that processor. Virtual Box works on even some of the low-end computers and that specific processor you listed is still very powerful by today's fulfillment.
I used this processor overclocked at 4.5ghz with a VM with no issues before I accidentally chipped the plating on it. One of the best generations of Intel processors. If you're getting it considerably cheaper than a 4th gen, I highly recommend it.