I would set UAC to the highest level: "always notify" for added protection against UAC bypasses.
You have 3 adblockers installed? Adblock Plus; AdGuard and Ghostery? I would suggest keeping only one: AdGuard.
What browser do you use?
Windows Defender can be enhanced by ConfigureDefender made by our own @Andy Ful :
Post updated in December 2025 ConfigureDefender utility for Windows 10/11. New stable version 4.1.0.0 is available on the developer website (updated in February 2025): https://github.com/AndyFul/ConfigureDefender Softpedia...