I would set UAC to the highest level: "always notify" for added protection against UAC bypasses.
You have 3 adblockers installed? Adblock Plus; AdGuard and Ghostery? I would suggest keeping only one: AdGuard.
What browser do you use?
Windows Defender can be enhanced by ConfigureDefender made by our own @Andy Ful :
Post updated 21.07.2024 ConfigureDefender utility for Windows 10/11. New version 4.0.0.1 is available on the developer website (updated in July 2024): https://github.com/AndyFul/ConfigureDefender Softpedia (ver. 4..0.0.1)...