Funny you mention that combo- i been monitoring WVSX progress on one of my systems Windows 10 and it sure is a potent interceptor. Dug out an old malware from XP i kept for years that can still reek havoc even on Win 10. Mainly a joke type program but is in the same class as ShellLocker ransomware in that it's full screen lock makes it near impossible to browse around to kill it with task manager etc. I submitted it to WVSX and the next day they already had it johnny-on-the-spot capturing that bug in advance. I mean just the mouse pointer movement of such files (indicative of AV's Real-Time) and WVSX jumped right on it.
Defender just seems so laggy sometimes and of course sports good misses that once skipped (like in
@cruelsister 's video test) the endpoint is already compromised and damage done.