Enable UAC & Smartscreen.
Implement some type of system & data backup solution as well as backing up important data to an external drive.
Consider adding an additional on demand scanner(s).
Thanks for sharing your config
If you're looking for a lightweight solution, there are somethings that you could do.
Move SecureAPlus to Real-time Malware Protection. It will catch what Windows Defender doesn't.
Switch Malwarebytes for another second opinion scanner. Malwarebytes runs in the background, eating up memory, even though you only use it to occasionally scan. Some good ones include Zemana Anti-Malware Portable, Emsisoft Emergency Kit (although it does take up quite some storage for its signatures), and Norton Power Eraser.
Other than that it looks great! Thanks for sharing!