This malware has a few variants which are delivered via weaponized documents, spam attachments, and phishing links. In most cases, the malware will be prevented by SmartScreen or Windows Defender (ConfigureDefender HIGH Protection Level).
The HIGH Protection Level is similar to the protection of any commercial AV, and such protection can be strengthened by additional settings at the cost of usability.
For example, when using KIS you could tweak Application Control to block/restrict scripting engines. When using WD you could add more ASR rules (ConfigureDefender MAX Protection Level) and use SysHardener, or H_C. If your friends are not happy-clickers, then they could use just standalone RunBySmartScreen.
There is no bulletproof protection. Anyway, the chances that one of your friends can be infected by such malware, when using WD with ConfigureDefender HIGH Protection Level, are much less than the chances of stealing her/his computer. So, you can stop thinking about it.
