ReHIPS; beta testers + development.
ReHIPS does not use User or Kernel Mode Hooks like just about every other security soft; it uses Windows' own built-in protection mechanisms. It is very stable.
However, it is still a young product and needs some further usability and compatibility improvements. The developers are committed to implementing things and have a road-map for ReHIPS in-place.
At the same time, even though it is still a young product, it is stable and will work fine on a production system. If you learn how to use it, then it will protect your system.