There were some minor issues with it. Sometimes (usually when my computer had not been rebooted for a number of days), the popup alerts would appear as a solid black box with nothing visible. This could be fixed with a reboot, but was still annoying. I can't remember if I tried exiting PC Manager for the system tray icon and reloading it. I presume I did, as I don't know why I wouldn't have done that.
Secondly, it can't quarantine items that are runnning. If detects a runinng process as being bad, it will try to quarantine it but will fail to delete the original file after quarantining it (but you will not be told this), as it appers it does not try to end running processes before deleting them.
Also, I just thought I'd try something different as I'd been using PC Manager for at least a few months.