How to stop\defend against scriptors ? = Don't install the interpreter and use an anti-executable (e.g. NVT ERP).
You can use Comodo products - which will sandbox Unrecognized script files, but be forwarned that there are scripts that can "reach outside" the sandbox and make permanent changes to the system - like deleting files (I just submitted one to Comodo Engineering).
Of course, you can set the Comodo sandbox to Block any Unrecognized file - and that will include scripts.
Unless you are an indiscriminate downloader\installer I wouldn't worry about it too much. Plus, you won't be installing Python, perl, AutoIT interpreters and running those type scripts, so the issue really is moot.
You are much more likely to experience a drive-by download of the javascript (.js) variety than anything else - which Comodo will handle either with via the sandbox or HIPS (I use HIPS - but it causes novices more mistakes than anything else since rule creation is not clear in some CIS HIPS alerts).
Comodo does much better at protecting against scriptors than all other suites I have tested. The user can just go with the default sandbox settings = Fully Virtualized or for maximum security set it to Block (all Unrecognized files).
Comodo isn't absolutely perfect, but then, nothing IT ever is... it's got you covered in the vast majority of scriptor cases.
Anti-executable configuration settings are included in CIS because that is an option for the user - as part of the Comodo default-deny protection model.
I can tell you from a lot of testing that it really does work.