WDAC on Windows 10 ver. 1903 (also Home and Pro ed.) is great if you use Windows Defender and mostly Microsoft applications or applications from Microsoft Store.
One can prepare a pretty nice and very secure setup, which will work flawlessly with simple WDAC policies and without user intervention (no need to do whitelisting when installing/updating applications).
For example:
Web browsers (from Microsoft, AppContainer support):
Microsoft Edge (Windows built-in), Microsoft Edge Dev (Chromium-based)
One can use Office Online extension for editing MS Office documents.
Apps from Microsoft Store:
Office document viewers:
Microsoft (Excel, Word, PowerPoint) Mobile
Office document editors (all not in APPContainer):
Neat Office (based on Libre Office), Ultra Office from CompuClever (based on Libre Office), WPS Office 2019 for Microsoft Store.
PDF viewers (all in AppContainer):
Adobe Reader Touch, Foxit MobilePDF, PDF Viewer Plus (from GSnathan), PDF Reader (from Kdan Mobile), Perfect PDF Reader (from soft Xpansion), Xodo PDF Reader & Editor (superfast for big documents).
Other applications:
Adobe Photoshop Express (APPContainer), Foobar2000 Mobile (APPContainer), Microsoft Whiteboard (APPContainer), Microsoft To-Do (APPContainer), Microsoft OneNote (APPContainer), MusicBee for Microsoft Store (not in APPContainer), Skype (APPContainer), Spotify for Microsoft Store (not in APPContainer), VLC for Microsoft Store (APPContainer), Wunderlist (APPContainer).
There are many other possibilities, I have chosen only the best.
Advanced users can also install the normal (desktop) applications in "Program Files ..." folders. But installing/updating such applications work best when WDAC protection is temporarily turned off.
Turning On/Off WDAC is very simple - just copy/delete the predefined SIPolicy.p7b file.