Paranoid users should block all sponsors, and delay Windows Updates. Then updating may be done with unblocked sponsors. The blocked sponsors can interfere with updates very rarely. I installed Windows Vista, Windows 7, Windows 8, Windows 8.1, Windows 10, several times with upgrades and hundreds of updates. Only one update in Windows 10 FCU failed (one month ago). I simply unblocked the sponsors, and the update finished successfully.
But the most effective protection is not using MS Office, not allowing macros, and using the protected PDF viewer.
Thanks, so it sounds like you often run with many sponsors blocked. Do you happen to have a list of sponsors you block? Hard Configurator manual shows a screenshot where I see some but I am not of what is the complete list you happen to like.