VBScript is a programming language used to create small programs, or to automate a series of commands, but it is also used to write malware (for example the old "I LOVE YOU" malware and its variants).
I remember the Windows Scripting Host (WSH) which is used for the interpretation and execution of files written in VBScript (extension .vbs) and it was present on the older Windows versions, it is probably still used on Windows 10, but please correct me if I'm wrong.
However, the danger of the Windows Scripting Host is in the automatic execution of associated scripts without the intervention of the user, to have access to the Windows shell, to the system files and to the registry, and this of course can be critical if it is done with a VBS malware.
But usually, any good AV has a Script Blocking function that protects from the execution of VBS malicious codes.
I also remember a modification to the Windows registry to disable the WSH engine in the old Windows OS but honestly I can't be more precise.