Why mess with any of them, you could always throw Process Explorer/Autoruns on your desktop in a folder "portable version" so if you get tired of it and want to delete it and re-add it the next day, it does not trash your file system, and use this with the 70 some odd/even engines to scan your running processes/Start-up entries, which really is all that matters. Inert files sitting on your system are causing you no harm, although I do believe it does excite anxiety in some.
Tools as such are excellent analysis tools that combined with knowledge will help you identify any issues. Learn about malware, where it drops and how, know where to look in your file system manually.