You guys don't understand what you're doing then complain, core isolation is enabled by default (in systems that support it), while memory integrity is turned OFF due to Software incompatibilities (since the tech is still green and needs developers to port it over).
So by forcing memory integrity ON while not knowing what the hell you doing will always result in problems, also despite the bug (of not being able to turn if OFF in the UI), memory integrity will turn itself OFF if there's compatibility problems.
It was also made clear you can fix the problem by regedit.
I suggest doing some research before messing with Windows Settings.