Well when you take the Dev's words literately it is true what Florian says. MemProtect can be installed with a right click of a mouse (within a second). The program has no graphical user interface, so it requires no interaction
From a user perspective you are right, it does not work out of the box. Be careful make a backup/restore point first because it uses Windows build in mechanisms to prevent process memory manipulation (called 'protected processes' feature). Even High Integrity Level processes (like Admin and System) are blocked by this protected processes feature.
There is no smarter and safer anti-exploit protection available on the market IMO. It is smarter than any other because it uses Windows mechanisms, so no incompatibility issues with other (security) software It is safer because it is a hardening mechanism (taking away the option to manupulating other processes memory, injecting DLL's or using their credentials with process hollowing).