If you really understand your OS, and how to configure Appguard, the protection in the newer versions is not significantly improved for home users.
The newest version has lsass protection, which is new, but that is mainly important for a business network, it is not so important for a home environment.
But if you are not expert in your OS and in Appguard configuration, don't use v4 without getting the relevant advice from the pros. There are important configuration changes needed in order to optimize it to Windows 10 and Office 365.